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doi: 10.1177/030098588802500602

Gastroenterology 138 , 185196 (2009)

Many NGP candidates are significant contributors to butyrate and propionate pools, thereby supplying energy substrates for colonocytes, enhancing epithelial barrier function, and exerting epigenetic and anti-inflammatory effects through HDAC inhibition and G-proteincoupled receptor signaling (96)

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This is mainly mediated by pyruvate carboxylase (PC) [38], an astrocyte specific enzyme that catalyzes the formation of oxaloacetate from pyruvate
