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Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients

Estrogens and estrogen quinone metabolites can have the same damaging effects as ROS, alkylate, or damage the integrity of DNA and proteins, and also bind to estrogen receptors and activate estrogen response elements, which leads to increased levels of ROS [275]

Recovery of the GSH content is provided not only by de novo synthesis, but also by the recycling of GSSG to GSH in the reaction catalyzed by glutathione reductase (GR) in the presence of NADPH(H + ) as the cofactor [3]

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