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the immune response, the metabolism of toxins and carcinogens

Cancers 2018 , 10 (11) , 409

found increased DNA methylation levels on several CpG nucleotides upstream of miR-4715-3p in upper gastrointestinal adenocarcinoma (UGC) tissue samples, which binds to the 3' untranslated region (3' UTR) of Aurora kinase A (AURKA) to inhibit its expression[120]

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Recently intriguing findings have emerged that both genetic and epigenetic alterations equally contribute to ESCC with collusion between them, which provides novel theories and understandings about therapeutic effect evaluation, potential therapeutic targets and prognostic prediction in ESCC patients [18]