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The p533 KR mutant, which is deficient in acetylation, does not induce cell cycle arrest or apoptosis but can downregulate SLC7 A11, promoting glutathione depletion and facilitating ferroptosis under ROS-induced stress [28]
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Exp Biol Med (Maywood) (2019) 244:63045
Amino acid deficiency can directly disrupt the TCA cycle and the respiratory chain, leading to cellular energy failure
