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First, the number of subjects was small

ElokilAABhuiyanAALiuH-ZHusseinMNAhmedHIAzmalSAet al

This results in the accumulation of electrons which can trigger ROS generation, as well as an accumulation of acyl-CoA which further disrupts mitochondrial function and signaling

We would suggest doing your own reading of both sides of the argument here before making any conclusions
however, those receiving amitriptyline or placebo also improved in these parameters, and the differences between groups were not statistically significant for most endpoints
