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Article contents Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Allostery: allosteric networks and allosteric signaling bias Published online by Cambridge University Press: 18 November 2025 Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Abstract Allosteric communication is established by networks through which strain energy generated at the allosteric site by an allosteric event, such as ligand binding, can propagate to the functional site

This effect may also be linked to the upregulation of the tryptophan metabolism pathway observed in the AMP group, which is hypothesized to mitigate excessive activity and anxious behaviors under stress conditions (27)

The samples were then centrifuged at 2,000 g for 15 min at 4C to separate the serum

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