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It has been reported that IGFBP-3 binds to a nuclear receptor, 9-cis retinoic acid receptor-alpha (RXR-), which interacts with peroxisome proliferator activated receptor-gamma (PPAR-), a nuclear protein involved in the regulation of glucose and lipid metabolism [175, 176]

gut, nerve repair) is the exceptionthose cases benefit from non-localized dosing

Last updated 8/29/2013

Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, et al
When investigating B12 deficiency, it's important to check folate status as well, as the two deficiencies often coexist
