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Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes

Investigations to elucidate the missing links between the PK, surrogates of response, and ultimate clinical response have the potential to increase the direct impact of the literature reviewed in this report

One cant simply deny the fact that the pain isnt there, as that would lead to even more stress