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59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility

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We will mention nanomedicine-based methods for diagnosing and treating this disease and try to fully explain the different mechanisms involved in the therapeutic potential of these types of treatments

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