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However, Wei et al

It has been demonstrated that exercise restores negative input in the hippocampus and restores the proper output of the HPA axis, as physical exercise increases dendritic complexity and the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, which is primarily involved in brain processes related to learning, memory, and cognition [65,109]

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they recruit cAMP response element-binding protein (CREB)-binding protein (CBP) or receptor-associated coactivator 3 (RAC3), to facilitate the transactivation of NRF2 target genes [146, 147]

fumigatus has also been described as a protease with broad proteolytic activity, including activity against the complement components C3, C4b, C5, and C1q, downregulating of complement cascade (Behnsen et al., Aspergillus spp