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Here's what separates a quality product from a filler-heavy option: What to look for: Transparent dosing: Each ingredient listed with its exact amount, not hidden in a "proprietary blend" Clinically meaningful doses: Enough glucosamine to actually reach therapeutic levels (see the dosage table above) Chondroitin sulfate: Ideally combined with glucosamine, not added as a trace ingredient MSM (methylsulfonylmethane): Provides organic sulfur for cartilage structure and has anti-inflammatory properties