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For example, a study on the co-encapsulation of astaxanthin and kaempferol demonstrated that, compared to nanoparticles encapsulating astaxanthin alone, the combined formulation exhibited significantly stronger antioxidant activity and lipid-regulating gene expression in RAW264.7 and HepG2 cells, indicating a pronounced synergistic effect (90)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Kalogjera L., Krezic I., Smoday I.M., Vranes H., Zizek H., Yago H., Oroz K., Vukovic V., Kavelj I., Novosel L., et al