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The expression of the identified targetsat both the RNA and protein levelsneeds to be measured between groups with induced excitotoxicity, excitotoxicity + ASM, and excitotoxicity + ASM + antioxidants

The volume of BAC water added depends on the desired concentration

No representations are made regarding biological activity, physiological outcomes, or experimental effects

However, it is increasingly clear that CRH receptors also couple to Gi (inhibiting adenylate cyclase) and Gq (stimulating phospholipase C, the processing of phosphatidylinositol 4,5-bisphosphate into inositol trisphosphate and diacylglycerol and intracellular Ca 2+ release), as well as the recruitment of beta-arrestins which counter-regulate CRH-R function via G-protein decoupling and receptor internalization/desensitization (52)

10.1021/acs.jpcb.5b12618 [DOI] [PubMed] [Google Scholar] Topalian S