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In order that these findings may reach as wide a readership as possible, we are placing this brief but important report under the heading Generalia

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Zinc intakes and health outcomes: an umbrella review

The severity of MELAS is influenced by heteroplasmy levels, with symptoms typically manifesting before the age of 20 and more severely in cases of high mutation loads presenting in infancy with developmental delays

Neurochem Res 14:353358 Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, OBrien R, Hohman TJ, Legido-Quigley C, Thambisetty M (2020) Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study