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In breast cancer cell studies, oleandrin primarily activates ATF3 and CHOP through the PERK-eIF2-ATF4 and IRE1-XBP1 axes, inducing ER stress, which ultimately leads to CRT translocation to the cell surface, providing a Eat-me signal for DCs [129]

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Intravenous administration of this treatment allows it to operate internally by skin-lightening while smoothing texture and reducing color irregularities in the skin

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Main P.A., Angley M.T., ODoherty C.E., Thomas P., Fenech M