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Pharmacogenetics 1994
10.1111/j.1742-4658.2011.08027.x
The role of 2,3-DPG in O 2 unloading has led to the development of synthetic allosteric effectors aimed at modulating Hb oxygen affinity in clinical contexts, especially for the treatment of ischaemia-related diseases such as sickle cell disease (Reference Ahmed, Ghatge, Safo, Hoeger and Harris68)
