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doi: 10.1016/j.freeradbiomed.2010.01.038

Experimental and clinical data suggest that melatonin exerts its anti-inflammatory effects by modulating both pro- and anti-inflammatory cytokines in various pathophysiological situations 73,74

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Thus, in addition to lactate production, some pyruvate is also oxidized into acetyl CoA and enters the TCA cycle, not to obtain ATP but to capture intermediate compounds to use as biosynthetic precursors