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Only the loci that exhibited statistically significant differences between the compared groups were chosen for further analysis

Key Takeaways Joe Rogan has discussed peptides on multiple JRE episodes: Conversations with Andrew Huberman, Derek (More Plates More Dates), and others cover various peptide compounds BPC-157 and TB-500 are frequently mentioned: Rogan has discussed these compounds in the context of recovery and tissue research Thymosin Alpha-1 and Ipamorelin also cited: Mentioned specifically on his Flagrant podcast appearance All peptides discussed are research compounds: Not FDA-approved medications for human treatment Published preclinical research exists: This article cites the peer-reviewed studies on compounds Rogan has mentioned Joe Rogan's podcast is the most popular on Spotify, with millions of downloads per episode

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However, passive absorption may be well below 1% in many patients,60 and high biliary B 12 excretion may add to a negative B 12 balance.59 Prospective studies on this topic have focused mainly on normalising serum B 12 concentrations and should be interpreted with caution since the specific goal of treatment in symptomatic B 12 deficiency is alleviating symptoms.92326 A recent Cochrane Review found that available studies only provide very low quality evidence that oral B 12 is as efficacious as intramuscular B 12 in improving symptoms.13 A recent survey of 204 patients suggested that oral B 12 was associated with less effective symptom improvement than parenteral treatment.61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent.24 Patient experiences Data from a review of patient experiences and surveys involving more than 2200 patients with B 12 deficiency in the UK indicate that many patients have concerns related to healthcare quality, safety, and treatment,626364 with nearly two thirds of respondents reporting that their treatment is insufficient to manage symptoms.2425 Some patients may experience recurrence or worsening of symptoms when the interval between injections is extended or extended too quickly, and report that continuation of frequent intramuscular hydroxocobalamin injections, varying between twice weekly and once every three to four weeks,65 is needed to remain asymptomatic

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