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Efforts should also be directed toward improving the pharmacokinetic properties, such as stability and bioavailability, and investigating targeted delivery mechanisms to enhance therapeutic efficacy while reducing off-target effects

Liu and colleagues also noted increased vitamin B6 catabolism and folate biosynthesis but reduced arachidonic acid biosynthesis in the insomnia group [213]

It activated the SLC7A11/GPX4 signaling pathway, upregulated GSH-Px and GSH expression, decreased MDA and ferroptosis levels, and inhibited lipid peroxidation and ferroptosis in the cerebral cortex, thereby improving motor function, balance, and neurological deficits in the rats

Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, et al
