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cAMP directly, or via PKA, activates RAP-1/B-Raf/ERK pathways, and potentially inhibits Raf-1 activated ERK activity

(D) MCF7 cells were exposed to 10nM -estradiol (-E2) 40nM sodium selenite (Se)

This nano-PROTACs effectively suppressed aerobic glycolysis by downregulating cellular myelocytomatosis viral oncogene homolog (c-Myc, a critical regulator of glucose metabolism), and concurrently inhibited the expression of programmed death-ligand 1 (PD-L1), thereby improving the chemotherapeutic effect of DOX