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Initial titration over 714 days allows researchers to identify dose-limiting side effects before committing to higher therapeutic doses

Next, 10 L of each cell line was mixed with 70 L matrix and 60 L medium and given to each well of the loaded 96-well plate (Figure 1A)

explored various CD38/CD47 BsAbs, each with unique in vitro properties: IMM560526B4 displayed the most potent inhibitory effect on CD38 enzymatic activity, while IMM560512C10 was effective in directly killing MM cells and completely eradicating established tumors in mouse models (69)

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