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Furthermore, most flavonoids are transformed into biologically active compounds by intestinal bacteria, highlighting the interrelatedness of gut microbes, nutrition, and brain health

Induction of apoptosis was detected by Propidium Iodide (PI, 1 g/mL) (Sigma Aldrich) and Annexin-V-APC (Immunotools) staining, followed by flow cytometry analysis, using a BD FACSCantoII flow cytometer

doi: 10.1080/00365513.2019.1658215

And when it comes to side-effects, a nutrient vs something cooked up in the lab no comparison