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Description
The heavy GCLC is both the catalytic unit and the regulatory site of GSH feedback inhibition, while the light subunit regulates the activity of the holo-enzyme by modulating the affinity of the two regulatory sites of GCLC, that for glutamate and that for glutathione thereby making the enzyme more efficient and less sensitive to feedback inhibition

Cell type-targeting nanoparticles in treating central nervous system diseases: challenges and hopes

doi: 10.1001/jama.2015.18318

BCs and ACs extend neurites into the IPL, where they synapse onto RGC dendrites [23]

A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda