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A mutation in the insulin 2 gene induces diabetes with severe pancreatic b -cell dysfunction in the Mody mouse
Genetically encoded rxYFP or roGFP2 probes have also become extremely valuable tools for noninvasive, ratiometric real-time redox measurements in various compartments, cells, and organisms 6471

This has been almost impossible to achieve since any attempts to do so have largely failed or produced only small increases over a protracted time frame

78.Lin CC, Chang KY, Huang DC, Marriott V, Beijsterveldt LV, Chen LT, et al
DNA repair enzymes can also be inhibited by RNOS