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Mechanism of Action (as reported in preclinical literature)

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The TIMP was added solely based on the concerns raised by the IRB, and this motor test will mainly be used as a tool for the DSMB when deciding whether the study should continue or not

Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases