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Moreover, additional X-ray crystallography and molecular dynamics data have demonstrated that the YTHDFs all interact with m6A mRNAs in the same way (103)

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In particular, a systematic review of 5632 patients concluded that augmentation therapy has a slight effect in reducing the decline in lung function, showing a 23% slowdown in the decline of forced expiratory volume in one second (FEV1) (13.4 mL/year, 95% CI 1.5-25.3 mL/year) in treated patients compared to the placebo group ( Additionally, a longitudinal study on 96 patients with severe AATD analyzed the rate of FEV1 decline before and after the initiation of weekly augmentation therapy, showing a slower decline in FEV1 in patients with mild airflow obstruction during treatment ( Regarding long-term clinical trial data on patient outcomes such as the frequency of exacerbations, quality of life, need for lung transplantation, and mortality, these remain more limited ( The effect of AAT therapy in reducing exacerbations has been described in patients with severe COPD