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In primary erythroid cells, mis-splicing of TMEM14C is implicated in ring sideroblast formation in myelodysplastic syndrome ( 4.1.5 Transfer of PPIX From PPOX to FECH Metabolic enzymes have long been shown to exist in macromolecular complexes that localize to specific subcellular localizations, with enzymes in the same pathway clustering together (Robinson and Srere, 1985
USA 102 , 82938298 (2005)
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The mechanism of itaconate-mediated inhibition of these enzymes is via alkylation of cysteine residues as well as by acylation of lysine residues
