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Since serum B12 concentrations do not always mirror the clinical picture, this marker is not optimally suited to monitor the effect of treatment, although it can help uncover a lack of patient compliance and malabsorption of oral B12 treatment

The biomarker methylmalonic acid in urine is sensitive, detecting early functional vitamin B12 deficiency before the onset of macrocytic anemia, as noted for MMA in serum

One study suggests that you absorb three per cent at doses of 50 micrograms (thats just 1.5 micrograms) but only 1.3 per cent at doses of 1,000 micrograms (13 micrograms)

Obese Zucker rats treated with AOD-9604 at 500 mcg/kg/day for 19 days showed a statistically significant reduction in body fat compared to vehicle-treated controls

Its also important to note that dogs with severe deficiencies or malabsorption issues may respond better to injectable B12 than an oral supplement