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As well as causing B12 deficiency, an increase in methylmalonic acid occurs, which is thought to result in loss of myelin in the peripheral nerves and, consequently, neuropathy, which may be symptomatic as early as 2 years into metformin treatment

Okabe and Amagase, 2005) would define agents action

Recent Prog Horm Res

[18] Frias JP, et al
