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Seitz R, Lerch L, Immel A, Egbring R

21 In fibroblasts 3T3/4A, GSTP1/JNK interaction occurring in the absence of stress stimuli also inhibits JNK activity and c-Jun phosphorylation

Importantly, in our previous research, we found that SIRT1 knockdown mice ( SIRT1 +/- mice) exhibits significant pre-eclampsia-like performances, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and narrow labyrinthine layer, while the manifestations could be reversed after intraperitoneally injecting SRT2104, which is a highly selective agonist of SIRT1[17]

[DOI] [PubMed] [Google Scholar] 121.Jackson K.D., Durandis R., Vergne M.J

Among various types of cancers, triple-negative breast cancer (TNBC) stands out as one of the most aggressive types, representing 1520% of all breast cancers and characterized by the absence of expression of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2)