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Peer review Peer review information Nature thanks Ashwin Ananthakrishnan, Andrew Mertens, Siddharth Singh and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Recently, two CDK2-specific inhibitors PF-07104091 (163) and BLU0298 (164) have been reported

Two weeks post-injury, we collected diseased lungs, separated pleura from deep lung tissue, and purified labeled matrix specifically from deep lung tissue via Streptavidin pull-down followed by mass-spectrometric proteomics of all tagged peptides (see Methods)

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However, no significant amounts of NAC-derived glutathione were detected in the blood plasma