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Therefore, targeting ENPP2 with RNAi leads to cholesterol accumulation by disrupting ENPP2-PPAR-LXR/ axis, and ultimately attenuates the migration and invasion of melanoma cells
[1] Creatine is a naturally occurring compound synthesized in the liver, kidneys, and pancreas from amino acids (arginine, glycine, and methionine)
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
doi: 10.1161/HYPERTENSIONAHA.109.144964 122 CrowleySDZhangJHerreraMGriffithsRRuizPCoffmanTM
The practical implications are significant
