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Notably, NU-0129, composed of siRNA targeting the GBM oncogene Bcl2Like12 (Bcl2L12) and a gold nanoparticle core, was the first spherical nucleic acid (SNA) drug administered systemically

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Hyperthyroidism is also common, but has the opposite effect, making more than enough thyroid hormone and disrupting thyroid function

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Further, a multivariate analysis was conducted to confirm the crude association observed with NAC

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Seager et al., 2021

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OR = 0.08, p = 0.029, respectively), and this seemingly surprising result might be based on the sex-, dose-, and metabolite-dependent effects of phthalates on the thyroid [73,109]

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