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Rather, the goal is to fundamentally change the joint's biology from a pro-inflammatory, degenerative state to an anti-inflammatory, pro-reparative one
Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

British Journal of Pharmacology

unusually flexible joints
