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Recurrence was confirmed through various means, including endoscopic biopsy, surgery, or imaging studies, such as abdominopelvic CT, positron emission tomography, or whole-body bone scan

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Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

Anecdotal reports suggest administering reduced dosages over cycles lasting 8-12 weeks