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They target different cell populations and different aging mechanisms

Turner RS, Thomas RG, Craft S, et al

Transl Psychiatry 7 , e1215 (2017)

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Delta-cell-specific Lepr ablation in the mouse results in normal glucose homeostasis and insulin secretion No difference in weight was observed between Lepr and control mice on a high-fat or chow diet ( Figures 3A-D )