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Compounding this issue is the lack of validated pharmacodynamic biomarkers that directly link OSC exposure to antimicrobial efficacy in humans

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This is especially useful for people with B vitamin deficiencies who may feel tired or fatigued throughout the day

Glutamate is also a source of -KG through glutaminolysis, where glutamine is hydrolyzed into glutamate by GLSs (cytosolic GLS1 and mitochondrial GLS2) followed by glutamate conversion into -KG by GLUDs

This activation of Nrf2 signaling by EGCG exerts antioxidant effects, improves blood lipid levels, and enhances SOD activity [203]