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ACTH triggers the adrenal cortex to release cortisol and other hormones, aiding in energy metabolism, immune responses, and stress adaptation

Nomenclature of targets and ligands Key protein targets and ligands in this article are hyperlinked to corresponding entries in the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY (Harding et al ., 2018), and are permanently archived in the Concise Guide to PHARMACOLOGY 2017/18 (Alexander et al ., 2017a,b,c,d)

Degradation during GI transit is a real concern given its linear unmodified structure

doi: 10.1016/j.molcel.2010.10.004