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Biomed Pharmacother 62:23649 De Flora S, Bennicelli C, Camoirano A, Serra D, Romano M, Rossi GA, Morelli A, De Flora A (1985) In vivo effects of N -acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic com-pounds

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Therefore, GSH deficiency can amplify the destructive potential of OxS due to compromised antioxidant defenses