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Another recently completed phase 3 clinical trial called REDEFINE 2 , which included 1,207 adults with type 2 diabetes and overweight or obesity, found that after 68 weeks, CagriSema led to weight loss of almost 16% experts say the highest yet in the type 2 population, compared to other weight management drugs like tirzepatide (Mounjaro for diabetes, Zepbound for weight loss) and semaglutide

Some researchers find their optimal response at 1.0 mg or 1.7 mg

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Complementary to these data, single-cell RNA-sequencing of enteric sensory neurons indicate that they express genes encoding for many of the corresponding receptors including HTR3a (5-HT 3 receptor), Tacr1 (Neurokinin 1 (NK1) receptor), and Glp1r (GLP-1 receptor) [35, 36]