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Nevertheless, safety concerns remain as some compoundssuch as BHT and BHAhave been associated with potential toxicity

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Lancet Diabetes Endocrinol 7(12):938948 Song K, Hao Y, Tan X, Huang H, Wang L, Zheng W (2023) Microneedle-mediated delivery of Ziconotide-loaded liposomes fused with exosomes for analgesia

Considering that heme oxygenase-1 (HO-1) gene KO and treatment with zinc protoporphyrin IX (a HO-1 inhibitor) reduced Fe + levels and ROS-mediated LPO in PR cells, it has been proposed that HO-1 is a critical modulator of PR ferroptosis induced by atRAL (108)

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