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Together, these studies are building a mechanistic framework for how GPCRs and SLCs couple ligand binding to downstream signaling, and how that coupling can be selectively tuned by small molecules
Furthermore, the inability to easily retrieve these microspheres once administered poses challenges in scenarios where reversibility is required, such as removing contraceptive drugs to enable a return to fertility
Fimbriae enable a cell to attach to surfaces and to other cells
The data Lilly presented was apparently compelling enough to warrant that level of response
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