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Conversely, alternatively activated M2 macrophages, polarized by anti-inflammatory cytokines (IL-4/IL-13), actively contribute to tissue remodeling processes by promoting fibrosis and repair mechanisms

Fibrosis, overgrowth, sclerosis, and scarring of various tissues are attributed to the expansion of activated mesenchymal stromal cells (myofibroblasts), leading to excessive deposition of extracellular matrix components in basement membranes and interstitial tissues (Makena et al., 2023)

For instance, long-term supplementation with a cystine-based antioxidant compound is able to delay age-associated muscle loss [83]

Proc Natl Acad Sci 95:98319836 Crowley E, McDevitt CA, Callaghan R (2010) Generating inhibitors of P-glycoprotein: where to, now

Antibiotic resistance of bacterial biofilms
