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doi: 10.1007/s12035-020-02259-9 10 FedorowiczAMateuszukLKopecGSkorkaTKutryb-ZajacBZakrzewskaAet al

Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor and C/EBP

In summary, reconciling all discussed aspects relevant to insulin, IGF-1 improves insulin sensitivity by suppressing insulin and GH secretion and by improving insulin signalling indirectly reducing FFA flux