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When the environmental conditions are not conducive to normal growth, daf-2 signaling is downregulated, and nematodes arrest the development at the long-lived dauer diapause stage, storing large amounts of fat instead of transferring energy to the reproductive system [93]

2016, Childhood trauma predicts antidepressant response in adults with major depression: data from the randomized international study to predict optimized treatment for depression. Other risk factors include chronic medical conditions and substance abuse, both of which aggravate or contribute to the development of depression