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This cytokine induces its own expression in activated HSCs, thereby creating a self-perpetuating cycle of events, referred to as an autocrine loop

The so-called three elements refer to Heyi, Xila and Badagan

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Determination of the in vitro metabolic stability of NMY1009 and FCCP upon incubation with rat liver microsomes NMY1009 and FCCP were detected by LCMS/MS using the Agilent 1290 Infinity HPLC system (Agilent Technology, Waldbronn, Germany) coupled to a Q Trap 5500 hybrid triple quadrupole linear ion trap mass spectrometer (Applied Biosystems/MDS Sciex, Concord, Ontario, Canada)

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