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Description
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Using HD mouse and cell models, we demonstrated that TFEB and TFE3 are sequestered in muHTT aggregates, and muHTT proteins associates with LMP triggering the translocation of LGALS3 to the lumen of lysosomes, with a close relation between polyQ size and severity of these events
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Administration of LPS (10 g/mL) or GSSSG (less than 100 M) did not affect survival of cultured primary Mller cells and established microglial cells (BV-2)
