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Tanaka H., Nakamura K., Mizuno M., et al., Nonthermal Atmospheric Pressure Plasma Activates Lactate in Ringer's Solution for Antitumor Effects, Scientific Reports 6 (2016): 36282

PMID: 34897440

The underlying mechanism is believed to be associated with estrogens influence on critical brainstem regions integral to neurocardiovascular regulation (54)

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From a mechanistic perspective, these outcomes are mediated by multi-system endocrine adaptations, including suppression of the HPG axis, alterations in insulin and glucose-regulating hormones, reduced triiodothyronine (T3), elevated cortisol, and disruptions in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling [92]