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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

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In the context of Long COVID, where chronic neuroinflammation is a primary driver of cognitive dysfunction, the ability to epigenetically turn off inflammatory genes is a massive therapeutic advantage

Usually a follicle will go through a series of steps during the menstrual cycle, where regular maturation and ovulation will occur

Using a Cavalieri probe, we determined that GPX4 was significantly decreased in SN of PD brain compared with control SN (Figure 4A, B)