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The same knockout mice, however, present increased spine turnover and fail to downregulate spine dynamics at 2 weeks of age (Cruz-Martn et al., 2010)

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Our own research has shown that GHK promotes the migration of lung fibroblasts from aged mice (24 months old) in a dose-dependent manner (Figure 1), indicating that it can revert aged fibroblasts to a more youthful phenotype, potentially through the activation of mesenchymal progenitor cells